Journal of Korean Medicine Rehabilitation : eISSN 2288-4114 / pISSN 1229-1854

Fig. 2.

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Fig. 2. Epigenetic mechanisms. (A) Nucleotide: DNA wraps around histone octamers, (B) Histone modification: histone proteins may be modified by acetylation. The addition of an acetyl group to histone tails generally opens The chromatin structure could be modified by the addition of an acetyl group to histone tails, facilitating transcription factor binding, and enhancing gene expression, (C) DNA methylation: methylation of cytosine nucleotide in CpG rich sequences prevents the binding of transcription factors and generally silences gene expression. (D) RNA interference: post-transcriptional regulatory mechanisms include shRNA, siRNA and miRNA that bind RNA and induce their degradation. CpG: cytosine-guanine, shRNA: short hairpin RNA, siRNA: small interfering RNA, miRNA: microRNA.
J Korean Med Rehabi 2020;30:63-78 https://doi.org/10.18325/jkmr.2020.30.1.63
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