Fig. 9. The histological analysis of femoral fracture with hematoxylin & eosin staining (magnification ×400). C57/BL6 mice with femoral fracture were treated with 40 and 80 ㎎/㎏/day of CO/AS extract for 14 and 28 days. The damaged femur was isolated by removing the muscles around the bone and investigated the morphology by hematoxylin & eosin staining. Dashed lines indicate fracture section. Normal: mice without femoral fracture, Control: phosphate-buffered saline treated group after femoral fracture, CO/AS: Cnidium officinale and Angelica sinensis (40 and 80 ㎎/㎏/day) extract treated group after femoral fracture, Tramadol: tramadol (20 ㎎/㎏/day) treated group after femoral fracture.
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