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A Systematic Review of Bee Venom Acupuncture for Knee Osteoarthritis
J Korean Med Rehabil 2017;27:47-60
Published online July 31, 2017;  https://doi.org/10.18325/jkmr.2017.27.3.47
Copyright © 2017 The Society of Korean Medicine Rehabilitation.

Ji-Hyang Gu, K.M.D., Eunseok Kim, K.M.D.*, Yang-Chun Park, K.M.D., In Chul Jung, K.M.D., Eun-Jung Lee, K.M.D.

Departments of Korean Rehabilitation Medicine, Acupuncture & Moxibustion Medicine*, Internal Medicine, Neuropsychiatry, College of Korean Medicine, Dae-Jeon University
Correspondence to: Eun-Jung Lee, Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dae-Jeon University, 75 Daedeok-daero 176 beongil, Seo-gu, Daejeon 35235, Korea
TEL (042) 470-9128
FAX (042) 470-9005
E-mail jungkahn@hanmail.net
CO-CORRESPONDING TO : In Chul Jung, Department of Neuropsychiatry, College of Korean Medicine, Dae-Jeon University, 75 Daedeok-daero 176beongil, Seo-gu, Daejeon 35235, Korea
TEL (042) 470-9129
FAX (042) 470-9486
E-mail npjeong@dju.kr
Received June 20, 2017; Revised July 7, 2017; Accepted July 15, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objectives The aim of this research is to assess the effects of bee venom acupuncture for knee osteoarthritis.
Methods For a systematic review, we constructed a key question as the effect of bee venom acupuncture for knee osteoarthritis and selected RCTs and nRCTs. We searched the following 15 databases without a language restriction: Pubmed, EMBASE, Cochrane CENTRAL (CENTRAL), CINAHL, AMED, seven Korean medical databases (KoreaMed, Kmbase, KISS, NDSL, KISTI, Koreantk, OASIS) and three Chinese databases including CNKI, Wanfang and VIP database.
Results A total of 300 potentially relevant studies were identified; only 13 studies were selected for systematic review. Almost studies showed that bee venom acupuncture has significant effect on knee osteoarthritis. 5 studies comparing bee venom acupuncture with acupuncture were included in the meta-analysis. The effect size of standardized mean difference (SMD) was analyzed as 'small effect' with 0.47 (95% CI: 0.10∼0.83, Z=2.49, p=0.01).
Conclusions The research showed that bee venom acupuncture can significantly reduce pain, stiffness and improve the quality of life of patients with knee osteoarthritis. However, most of the studies included in the analysis were evaluated as methodologically high risk of bias. This suggests that there is limitation applying this study. In the future, more Randomized Controlled trial should be actively conducted.
Keywords : Knee Osteoarthritis, Bee Venom, Systematic review, Meta-analysis


October 2017, 27 (4)