search for


J Korean Med Rehabi 2018 Oct; 28(4): 103-112  
Pathological Laughing and Crying following Midbrain Infarction: Case Report and Literature Review
Published online October 31, 2018
Copyright © 2018 The Society of Korean Medicine Rehabilitation.

So-Ri Moon, K.M.D., Seo-Hyun Park, K.M.D., Seon-Joo An, K.M.D., Dong-Ho Keum, K.M.D.

Department of Korean Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital
Correspondence to: Dong-Ho Keum, Department of Korean Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital, 268 Buljeong-ro, Bundang-gu, Seongnam 13601, Korea
TEL (031) 710-3728
FAX (031) 710-3780
Received: September 15, 2018; Accepted: October 1, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pathological laughing and crying (PLC) is a condition defined by relatively uncontrollable episodes of laughter, crying or both. PLC is an uncommon symptom usually caused by cerebral lesions. Midbrain involvement causing PLC is extremely unusual and the exact mechanism by which this condition develops is poorly understood. We recently experienced a 51-year-old woman who were diagnosed as PLC after midbrain infarction. She was treated by acupuncture, pulsed electromagnetic therapy (PEMT). After 6 weeks treatment, Pathological Laughter and Crying Scale (PLACS), Korean version of the Scale for the Assessment and Rating of Ataxia (K-SARA) are decreased and Korean version of Modified Barthel Index (K-MBI) is increased. Treatment of traditional Korean Medicine could be effective for stoke rehabilitation including post-stroke PLC. And we have considered mechanism of PLC associated with midbrain lesion, dysfunction of cortex-thalamus-hypothalamus-basal ganglia-mesencephalon and faciorespiratory nuclei pathways, cerebro-ponto-cerebellar pathways and damaged serotonergic neurotransmission can cause this based on recent neurobiology of emotion. To define exact mechanism and find effective treatment, further studies are needed.
Keywords : Pathological laughing and crying, Midbrain infraction, Acupuncture, Pulsed electromagnetic therapy

October 2018, 28 (4)

Cited By Articles
  • CrossRef (0)

  • Crossref TDM
  • CrossMark
  • orcid