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J Korean Med Rehabil 2019 Apr; 29(2): 101-113  
Protective Effects of Bogol-tang on Monosodium Iodoacetate-induced Osteoarthritis and Interleukin-1β-treated Primary Chondrocytes
Published online April 30, 2019
Copyright © 2019 The Society of Korean Medicine Rehabilitation.

Jin Wook Sung, K.M.D.*, Hai Woong Lee, K.M.D., Kyung Hwa Kang, K.M.D., Kyoung Min Kim, K.M.D.§, Sung Woo Cho, K.M.D.*

Departments of Korean Rehabilitation Medicine*, Preventive Medicine, Physiology, and Oriental Internal Medicine§, College of Korean Medicine, Dong-eui University
Correspondence to: Sung Woo Cho, Department of Korean Rehabilitation Medicine, College of Korean Medicine, Dong-eui University, 52-57 Yangjeong-ro, Busanjin-gu, Busan 47227, Korea
TEL (051) 850-8671
FAX (051) 867-5162
Co-corresponding to: Kyung-Hwa Kang, Department of Physiology, College of Korean Medicine, Dong-eui University, 52-57 Yangjeong-ro, Busanjin-gu, Busan 47227, Korea
TEL (051) 850-7423
FAX (051) 853-4036
Received: March 14, 2019; Revised: April 15, 2019; Accepted: April 17, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Objectives Bogol-tang has clinically been used to protect joint cartilage and to treat osteoarthritis. Our objective was to study the protective effect of Bogol-tang extract (BGT) in functional impairment, behavioral disorders, cartilage loss and pathological changes in a monoiodoacetate (MIA)-induced murine osteoarthritis (OA) model and interleukin (IL)-1β-treated primary rat chondrocytes.

Methods Mouse knee joints were injected with MIA, a chemical that inhibits glycolysis and causes joint inflammation and matrix loss. MIA-OA induced mice orally administered BGT or acetaminophen (AAP) for 18 days by daily. Primary rat chondrocytes were pretreated with BGT or dexamethasone (DEX) and followed by co-incubation with IL-1β (10 ng/mL).

Results In MIA-OA mice model, BGT led to delayed response on hot plate analysis, and suppressed the cartilage loss and damages in joint tissues. BGT suppressed the elevated levels of inflammatory mediators, nitrite and PGE2, the gene expression of matrix degrading enzymes, and extracellular-signal-regulated kinases 1/2 and c-JunN-terminal kinase phosphorylation in IL-1β-treated primary rat chondrocytes.

Conclusions Our results suggest that BGT improve the knee joint function and delay the cartilage damages by anti-nociceptive, anti-inflammatory and ant-catabolic effects, which indicate BGT could be a potential candidate for osteoarthritis treatment.

Keywords : Bogol-tang, Osteoarthritis, Monosodium iodoacetate, Nociception

April 2019, 29 (2)

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